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Press ⌘K to jump anywhere, or pick a starting point belowHighest-expressing transportersCap EC % expressing
Drugs with a disease-shifted transporterAD / PD hits
About this toolBlood–brain barrier drug-permeability prediction from human single-cell transcriptomics
The BBB Transporter Atlas predicts whether a drug is likely to cross the blood–brain barrier by mapping it to the transporter genes it interacts with, then reading those genes’ expression in brain capillary endothelial cells from real human single-cell / single-nucleus RNA-seq. It combines an Aim 1 healthy baseline (mean expression across three independent human datasets) with Aim 2 disease shifts (how those transporters change in Alzheimer’s and Parkinson’s disease).
Aim 1 · 3 healthy datasets
Aim 2 · AD & PD disease shifts
26 transporter genes
38 curated drugs
This is a research prototype — not a clinical, diagnostic, or regulatory tool, and it is not FDA-approved or clinically validated.
Every permeability verdict is a hypothesis-generating prediction inferred from gene expression data, not a measured or validated pharmacokinetic result.
Do not use for patient care, dosing, or any clinical decision. See Methods & Known Limitations.
26 genes × 7 cell types × 3 datasets — Capillary EC column is the basis for permeability scoring. Hover cells for exact values.
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High — mean log-normalized expression (per-dataset scale)
Compare two genes or two drugs across their key data — expression, verdict, and disease shifts — without switching back and forth.